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Palladium-catalyzed coupling of amides and cyclopropanols for the synthesis of γ-diketones.

Lili FangShuqi JiaShuaixin FanJin Zhu
Published in: Chemical communications (Cambridge, England) (2023)
A palladium catalytic method has been developed for the coupling of amides and cyclopropanols to γ-diketones, through simultaneous C-N and C-C activation. Heteroatom ligand exchange and heteroatom-to-carbon ligation mode switching enable the achievement of molecular cross-coupling in an amide N-atom structural context-dependent manner, avoiding any stoichiometric organometallic reagent or base.
Keyphrases
  • room temperature
  • electron transfer
  • molecular dynamics
  • single molecule