Antibiotic release from PMMA spacers and PMMA beads measured with ELISA: assessment of in vitro samples and drain fluid samples of patients.

Daniël M C JanssenPaul WillemsJan A P Geurts Jacobus J Arts

Published in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society (2023)

This is the first study that measured the release data of local antibiotics with ELISA. Compare to spacers, the exact release values of gentamicin from PMMA beads are more than 10 times higher and reached a maximum much later than spacers. This makes the use of PMMA beads more preferable to use for treatment of the infection itself. This article is protected by copyright. All rights reserved.

Keyphrases

end stage renal disease
ejection fraction
chronic kidney disease
newly diagnosed
peritoneal dialysis
prognostic factors
electronic health record
machine learning
molecular dynamics
artificial intelligence