Interaction of Hepatitis B Virus X Protein with the Pregnane X Receptor Enhances the Synergistic Effects of Aflatoxin B1 and Hepatitis B Virus on Promoting Hepatocarcinogenesis.

Yongdong Niu Shaohua FanQin LuoLiming ChenDanmei HuangWenjun ChangWenxin Qin Ganggang Shi

Published in: Journal of clinical and translational hepatology (2021)

Our finding regarding AFB1 toxicity enhancement by an HBx-PXR-CYP3A4/ GSTM1-KRAS-IL11:IL11RA signaling axis provides a rational explanation for the synergistic effects of chemical carcinogens in HBV infection-associated hepatocarcinogenesis.

Keyphrases

hepatitis b virus
liver failure
cancer therapy
rheumatoid arthritis
oxidative stress
drug delivery
ankylosing spondylitis
wild type
interstitial lung disease