Interactions between kappa and mu opioid receptor agonists: effects of the ratio of drugs in mixtures.
Vanessa MinerviniHannah Y LuJahnavi PadartiDaniela C OsteicoecheaCharles P FrancePublished in: Psychopharmacology (2018)
Overall, mixtures of kappa and mu opioids might have therapeutic potential for treating pain, particularly when the mixture has a greater ratio of mu to kappa agonist. If adverse effects of each constituent drug are reduced or avoided, then kappa:mu mixtures might be advantageous to mu opioids alone.