Hypoxia regulates placental angiogenesis via alternatively activated macrophages.

Hui ZhaoFlora S KalishRonald J WongDavid K Stevenson

Published in: American journal of reproductive immunology (New York, N.Y. : 1989) (2018)

M2, particularly M2c, displayed strong pro-angiogenic potential, which decreased under severe hypoxia such as in early pregnancy. Thus, conditions that alter the placental oxygen microenvironment or macrophage response in early pregnancy might cause aberrant angiogenesis and vascular remodeling, and lead to abnormal placental vascular development.

Keyphrases

endothelial cells
vascular endothelial growth factor
stem cells
adipose tissue
early onset
wound healing
risk assessment
climate change