Single-cell transcriptome analysis deciphers the CD74-mediated immune evasion and tumour growth in lung squamous cell carcinoma with chronic obstructive pulmonary disease.

Denian WangSixiang LiZhi YangChunyan YuPengfei WuYing YangRui ZhangQingyan LiJian YangHongchun LiGuiyi JiYan WangKang XieYanyan LiuKaige WangDaxing ZhuWengeng ZhangDan LiuBojiang ChenWeimin Li

Published in: Clinical and translational medicine (2024)

T cells and impair their anti-tumour activity by regulating the PI3K-STAT3-PD-L1 signalling pathway, facilitating immune evasion.

Keyphrases

chronic obstructive pulmonary disease
squamous cell carcinoma
single cell
rna seq
cell proliferation
lung function
lymph node metastasis
locally advanced
rectal cancer