A traditional gynecological medicine inhibits ovarian cancer progression and eliminates cancer stem cells via the LRPPRC-OXPHOS axis.

Ruibin JiangZhongjian ChenMaowei NiXia LiHangjie YingJianguo FenDanying WanChanjuan PengWei ZhouLinhui Gu

Published in: Journal of translational medicine (2023)

Our study identified a therapeutic target and provided a corresponding inhibitor for OXPHOS-based OC therapy. GAA inhibits OC progression by suppressing OXPHOS complex synthesis via targeting LRPPRC protein, supporting its potential utility as a natural therapeutic agent for ovarian cancer.

Keyphrases

cancer stem cells
protein protein
binding protein
small molecule
drug delivery
mesenchymal stem cells