A Randomized, Open-Label Comparison of Once-Weekly Insulin Icodec Titration Strategies Versus Once-Daily Insulin Glargine U100.

Ildiko LingvayJohn B BuseEdward FranekMelissa V HansenMette M KoefoedChantal MathieuJeremy PettusKarolina StachlewskaJulio Rosenstock

Published in: Diabetes care (2021)

Once-weekly icodec was efficacious and well tolerated across all three titration algorithms investigated. The results for icodec titration A (80-130 mg/dL; ±21 units/week) displayed the best balance between glycemic control and risk of hypoglycemia.

Keyphrases

glycemic control
type diabetes
open label
blood glucose
weight loss
machine learning
insulin resistance
clinical trial
physical activity
deep learning
phase ii
squamous cell carcinoma
metabolic syndrome
phase ii study
adipose tissue
high resolution
clinical evaluation