Synthesis of C14-C21 acid fragments of cytochalasin Z 8 via anti -selective aldol condensation and B -alkyl Suzuki-Miyaura cross-coupling.

An efficient synthesis of the C14-C21 acid fragment of cytochalasin Z 8 was accomplished in 10 steps with 14% overall yield. Boron-mediated anti -selective aldol condensation and Pd(OAc) 2 -Aphos-Y-catalysed B -alkyl Suzuki-Miyaura cross-coupling were employed to construct the requisite C17 and C18 stereogenic centres and alkene subunit.