Obesity and Hyperphagia With Increased Defective ACTH: A Novel POMC Variant.

Eline S van der ValkLotte KleinendorstPatric J D DelhantyBibian van der VoornJenny A VisserM M van HaelstLaura C G de GraaffMartin HuismanAnne WhiteShosuke ItoKazumasa WakamatsuYolanda B de RijkeErica L T van den AkkerAnand M IyerElisabeth F C van Rossum

Published in: The Journal of clinical endocrinology and metabolism (2022)

The hyperphagia and obesity support evidence that adequate cleavage of ACTH to α-MSH and d-α-MSH is also required in humans for feeding control.

Keyphrases

insulin resistance
metabolic syndrome
weight loss
high fat diet induced
type diabetes
weight gain
adipose tissue
skeletal muscle
dna binding
physical activity
transcription factor