Decreased plasma gelsolin fosters a fibrotic tumor microenvironment and promotes chemoradiotherapy resistance in esophageal squamous cell carcinoma.

Chih-Hsiung HsiehPei-Shiuan HoWen-Lun WangFu-Hsuan ShihChen-Tai HongPei-Wen WangDar-Bin ShiehWei-Lun ChangYing-Jan Wang

Published in: Journal of biomedical science (2024)

Our results demonstrated that GSN methylation causes decreased secretion of pGSN, leading to integrin dysregulation, oncogenic TNC activation, and CAF formation. These findings highlight the role of pGSN in therapeutic resistance and the fibrotic tumor microenvironment of ESCC.

Keyphrases

systemic sclerosis
idiopathic pulmonary fibrosis
rectal cancer
dna methylation
locally advanced
squamous cell carcinoma
radiation therapy
cell adhesion