Inhibition of Cav 3.2 calcium channels: A new target for colonic hypersensitivity associated with low-grade inflammation.

Elodie PicardFrederic Antonio CarvalhoFrancina AgostiEmmanuel BourinetDenis ArdidAlain EschalierLaurence DaulhacChristophe Mallet

Published in: British journal of pharmacology (2019)

These results suggest that ethosuximide represents a promising drug reposition strategy and that inhibition of CaV 3.2 channels is an attractive therapeutic approach for relieving CHS in IBS or IBD.

Keyphrases

low grade
high grade
oxidative stress
drug induced
ulcerative colitis
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