Long Noncoding RNAs: New Players in the Osteogenic Differentiation of Bone Marrow- and Adipose-Derived Mesenchymal Stem Cells.
Qiaolin YangLingfei JiaXiaobei LiRunzhi GuoYiping HuangYunfei ZhengQiaolin YangPublished in: Stem cell reviews and reports (2018)
Mesenchymal stem cells (MSCs) are an important population of multipotent stem cells that differentiate into multiple lineages and display great potential in bone regeneration and repair. Although the role of protein-coding genes in the osteogenic differentiation of MSCs has been extensively studied, the functions of noncoding RNAs in the osteogenic differentiation of MSCs are unclear. The recent application of next-generation sequencing to MSC transcriptomes has revealed that long noncoding RNAs (lncRNAs) are associated with the osteogenic differentiation of MSCs. LncRNAs are a class of non-coding transcripts of more than 200 nucleotides in length. Noncoding RNAs are thought to play a key role in osteoblast differentiation through various regulatory mechanisms including chromatin modification, transcription factor binding, competent endogenous mechanism, and other post-transcriptional mechanisms. Here, we review the roles of lncRNAs in the osteogenic differentiation of bone marrow- and adipose-derived stem cells and provide a theoretical foundation for future research.
Keyphrases
- mesenchymal stem cells
- transcription factor
- bone marrow
- genome wide identification
- umbilical cord
- bone regeneration
- stem cells
- cell therapy
- dna binding
- genome wide analysis
- gene expression
- network analysis
- single cell
- genome wide
- insulin resistance
- copy number
- binding protein
- risk assessment
- dna damage
- metabolic syndrome
- skeletal muscle
- human health
- type diabetes
- oxidative stress
- protein protein
- amino acid