Sex-Specific Deflection of Age-Related DNA Methylation and Gene Expression in Mouse Heart by Perinatal Toxicant Exposures.

Kai WangMaureen A SartorJustin A ColacinoDana C DolinoyLaurie K Svoboda

Published in: bioRxiv : the preprint server for biology (2024)

Together these data show that perinatal Pb or DEHP exposures deflect normal age-related gene expression, DNA methylation programs, and cellular composition across the life course, long after cessation of exposure, and highlight potential biomarkers of developmental toxicant exposures. Further studies are needed to investigate how these epigenetic and transcriptional changes impact cardiovascular health across the life course.

Keyphrases

gene expression
dna methylation
air pollution
genome wide
pregnant women
heart failure
heavy metals
public health
electronic health record
atrial fibrillation
copy number
machine learning
risk assessment
case control
heat stress
data analysis