Mitochondrial alarmins are tissue mediators of ventilator-induced lung injury and ARDS.
Serge GrazioliIrène Dunn-SiegristLaure-Anne PauchardMathieu BlotPierre-Emmanuel CharlesJérôme PuginPublished in: PloS one (2019)
Mitochondrial alarmins are released during cyclic stretch of human epithelial cells, as well as in BAL fluids from rabbits ventilated with an injurious ventilatory regimen, and found in BAL fluids from ARDS patients, particularly in those with high alveolar inflammation. These alarmins are likely to represent the proximal endogenous mediators of VILI and ARDS, released by injured pulmonary cells.
Keyphrases
- acute respiratory distress syndrome
- mechanical ventilation
- oxidative stress
- extracorporeal membrane oxygenation
- end stage renal disease
- induced apoptosis
- intensive care unit
- ejection fraction
- chronic kidney disease
- endothelial cells
- newly diagnosed
- high glucose
- cell cycle arrest
- pulmonary hypertension
- drug induced
- patient reported outcomes
- cell death