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Evolution of CCL16 in Glires (Rodentia and Lagomorpha) shows an unusual random pseudogenization pattern.

Fabiana NevesJoana AbrantesAna M LopesLuciana A FusinattoMaria J MagalhãesWessel van der LooPedro J Esteves
Published in: BMC evolutionary biology (2019)
Our results suggest that while functional in the Glires ancestor, CCL16 underwent pseudogenization in some species. This process occurred stochastically or in specific lineages at different moments in the evolution of Glires. These observations suggest that the CCL16 had different evolutionary constrains in the Glires group that could be associated with the CCL16 biological function.
Keyphrases
  • liver fibrosis
  • liver injury
  • drug induced
  • gene expression