COVID-19 mRNA vaccines induce robust levels of IgG but limited amounts of IgA within the oronasopharynx of young children.
Ying TangBrittany P BoribongZoe N SwankMelina DemokritouMaria A F LubanAlessio FasanoMichelle DuRebecca L WolfJoseph GriffithsJohn ShultzElla BorbergSujata ChaliseWanda I GonzalezDavid R WaltLael M YonkerBruce H HorwitzPublished in: medRxiv : the preprint server for health sciences (2024)
Despite the induction of specific IgG in the oronasal mucosa, current intramuscular vaccines have limited ability to generate mucosal IgA in young children. These results confirm the independence of mucosal IgA responses from systemic humoral responses following mRNA vaccination and suggest potential future vaccination strategies for enhancing mucosal protection in this young age group.