Juvenile idiopathic arthritis associated with a mutation in GATA3.
Anna E PatrickWei WangElly BrokampThomas Brent GrahamThomas M AuneJessica B DuisPublished in: Arthritis research & therapy (2019)
Our research presents the first known case of autoimmune arthritis associated with a mutation in GATA3. This work expands the phenotypic spectrum of GATA3 mutations. It reveals the novel insight that decreased and altered GATA3 activity coincides with autoimmune arthritis. This work suggests that modulation of GATA3 may be a therapeutic approach for patients with autoimmune arthritis.