The relationship of tidal volume and driving pressure with mortality in hypoxic patients receiving mechanical ventilation.
Robert A RaschkeBrenda StofferSeth AssarStephanie FountainKurt OlsenC William HeiseTyler GalloAngela Padilla-JonesRichard GerkinSairam ParthasarathySteven C CurryPublished in: PloS one (2021)
Driving pressures ≥19 cmH2O were associated with increased adjusted mortality. TV/PBW 4-6ml/kg were used in less than 15% of patients and associated with increased adjusted mortality compared to TV/PBW 6-10 ml/kg used in 82% of patients. Prospective clinical trials are needed to prove whether limiting DP or the use of TV/PBW 6-10 ml/kg versus 4-6 ml/kg benefits mortality.
Keyphrases
- end stage renal disease
- mechanical ventilation
- clinical trial
- cardiovascular events
- newly diagnosed
- ejection fraction
- chronic kidney disease
- risk factors
- prognostic factors
- intensive care unit
- peritoneal dialysis
- type diabetes
- acute respiratory distress syndrome
- coronary artery disease
- cardiovascular disease
- patient reported