Virtual Screening and Optimization of Novel mTOR Inhibitors for Radiosensitization of Hepatocellular Carcinoma.
Ying-Qi FengShuang-Xi GuYong-Shou ChenXu-Dong GaoYi-Xin RenJian-Chao ChenYin-Ying LuHeng ZhangShuang CaoPublished in: Drug design, development and therapy (2020)
A new class of selective mTOR inhibitors was developed and their radiosensitization effects were confirmed. This study also provides a basis for developing mTOR-specific inhibitors for use as radiosensitizers for HCC radiotherapy.