Novel GLCCI1-BRAF fusion drives kinase signaling in a case of pheochromocytomatosis.
Benjamin L GreenRobert R C GrantChristopher T RichieBishwanath ChatterjeeMichelly Sampaio De MeloFrederic G BarrKarel PacakSunita K AgarwalNaris NilubolPublished in: European journal of endocrinology (2022)
This report is the first of GLCCI1 fused to BRAF in a human neoplasm and only the second BRAF-containing fusion transcript in PCC. Detailed molecular characterization of PCC can be a valuable tool in managing patients with recurrent PCC and pheochromocytomatosis that represents a significant clinical challenge.