Heterogeneity and Molecular Markers for CNS Glial Cells Revealed by Single-Cell Transcriptomics.
Junjie SunYixing SongZhiheng ChenJiaying QiuShunxing ZhuLiucheng WuLingyan XingPublished in: Cellular and molecular neurobiology (2021)
Glial cells, including astrocytes, oligodendrocytes, and microglia, are the major components in the central nervous system (CNS). Studies have revealed the heterogeneity of each glial cell type and that they each may play distinct roles in physiological processes and/or neurological diseases. Single-cell sequencing (scRNA-seq) technology developed in recent years has extended our understanding of glial cell heterogeneity from the perspective of transcriptome profiling. This review summarizes the marker genes of major glial cells in the CNS and reveals their heterogeneity in different species, CNS regions, developmental stages, and pathological states (Alzheimer's disease and spinal cord injury), expanding our knowledge of glial cell heterogeneity on both molecular and functional levels.
Keyphrases
- single cell
- rna seq
- neuropathic pain
- induced apoptosis
- high throughput
- spinal cord injury
- cell cycle arrest
- blood brain barrier
- spinal cord
- healthcare
- oxidative stress
- endoplasmic reticulum stress
- stem cells
- genome wide
- mesenchymal stem cells
- gene expression
- bone marrow
- transcription factor
- brain injury
- bioinformatics analysis