Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.

Michiyo IbaRoss A McDevittChangyoun KimRoshni RoyDimitra SarantopoulouElla TommerByron SiegarsMichelle SallinSomin KwonJyoti Misra SenRanjan SenEliezer Masliah

Published in: Molecular neurodegeneration (2022)

We propose that aging related inflammation (eg: CSF2) influences outcomes of pathological spreading of ɑ-syn and suggest that targeting neuro-immune responses might be important in developing treatments for DLB/PD.

Keyphrases

mouse model
immune response
oxidative stress
traumatic brain injury
resting state
cancer therapy
toll like receptor
cerebral ischemia
metabolic syndrome
drug delivery