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Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD.

Michiyo IbaRoss A McDevittChangyoun KimRoshni RoyDimitra SarantopoulouElla TommerByron SiegarsMichelle SallinSomin KwonJyoti Misra SenRanjan SenEliezer Masliah
Published in: Molecular neurodegeneration (2022)
We propose that aging related inflammation (eg: CSF2) influences outcomes of pathological spreading of ɑ-syn and suggest that targeting neuro-immune responses might be important in developing treatments for DLB/PD.
Keyphrases
  • mouse model
  • immune response
  • oxidative stress
  • traumatic brain injury
  • resting state
  • cancer therapy
  • toll like receptor
  • cerebral ischemia
  • metabolic syndrome
  • drug delivery