Investigating the effects of PTEN mutations on cGAS-STING pathway in glioblastoma tumours.

Eda DoganZafer YildirimTaner AkalinErkin OzgirayNevhis AkinturkCagdas AktanAsli Ece SolmazHuseyin BicerogluKadri Emre CaliskanYesim ErtanTaskin YurtsevenBuket KosovaVildan Bozok Cetintas

Published in: Journal of neuro-oncology (2024)

This study reveals the immunosuppressive effects of PTEN loss in glioblastoma tumours via the cGAS-STING pathway. Therefore, determining the PTEN status in tumours is of great importance, like in situations when considering the treatment of glioblastoma patients with immunotherapeutic agents.

Keyphrases

pi k akt
cell proliferation
innate immune