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Photoinduced Three-Component Difluoroalkylation of Quinoxalinones with Alkenes via Difluoroiodane(III) Reagents.

Ningning ZhouRuiyue LiuChunmeng ZhangKun WangJiaxu FengXia ZhaoKui Lu
Published in: Organic letters (2022)
An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine(III) reagents is disclosed. The new designed difluoroiodane(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxaline-2(1 H )-ones in moderate to excellent yields under mild conditions. Experimental studies demonstrated that a difluoroalkyl radical intermediate was involved in this reaction.
Keyphrases
  • electron transfer
  • high intensity
  • computed tomography