Decreased Penetrance of Parkinson's Disease in Elderly Carriers of Glucocerebrosidase Gene L444P/R Mutations: A Community-Based 10-Year Longitudinal Study.

Shaozhen JiChaodong WangHongwen QiaoZhuqin GuZiv Gan OrEdward A FonPiu Chan

Published in: Movement disorders : official journal of the Movement Disorder Society (2020)

Although GBA mutations may lead to an earlier onset PD, the majority of GBA L444P heterozygotes in older adults may not convert to PD. Further studies are warranted to identify factors that modify the risk of conversion. © 2020 International Parkinson and Movement Disorder Society.

Keyphrases

physical activity
genome wide
copy number
middle aged
community dwelling
gene expression
genome wide identification
transcription factor
dna methylation