Expressions of p53 and PUMA in fibroblasts of systemic sclerosis patients are normal at transcription level.
Mohammad Bagher MahmoudiMajid Abed KhojastehFereshteh AlsahebfosoulFarhad GharibdoostShayan MostafaeiMazdak Ganjalikhani-HakemiMahdi MahmoudiPublished in: Journal of cosmetic dermatology (2017)
Apoptosis pathways are impaired in fibroblasts from patients with SSc, leading to chronic fibrosis. Nonetheless, PUMA/p53 pathway may not be involved in dysfunction of apoptosis mechanisms in fibroblasts of patients with SSc.
Keyphrases
- systemic sclerosis
- oxidative stress
- interstitial lung disease
- end stage renal disease
- extracellular matrix
- endoplasmic reticulum stress
- cell cycle arrest
- ejection fraction
- cell death
- newly diagnosed
- chronic kidney disease
- peritoneal dialysis
- prognostic factors
- rheumatoid arthritis
- cell proliferation
- signaling pathway
- idiopathic pulmonary fibrosis