Targeting oncogenic microRNAs from the miR-371~373 and miR-302/267 clusters in malignant germ cell tumours causes growth inhibition through cell cycle disruption.

Shivani BaileyMarta FerraressoLuz Alonso-CrisostomoDawn WardStephen P SmithJames C NicholsonHarpreet SainiAnton J EnrightCinzia G ScarpiniNicholas ColemanMatthew Jonathan Murray

Published in: British journal of cancer (2023)

Targeting of specific miR-371~373 and miR-302/367 microRNAs in malignant GCTs demonstrated their functional significance, with growth inhibition mediated through cell cycle disruption.

Keyphrases

cell cycle
cell proliferation
long non coding rna
long noncoding rna
germ cell
transcription factor
drug delivery