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Inhaled alprazolam rapidly suppresses epileptic activity in photosensitive participants.

Jacqueline A FrenchRobert T WechslerMichael A GelfandJohn R PollardBlanca VazquezDaniel FriedmanLily H GongEdwin KamemotoJouko IsojarviJames V Cassella
Published in: Epilepsia (2019)
This proof-of-concept study demonstrated that Staccato alprazolam 0.5, 1.0, and 2.0 mg rapidly suppressed epileptiform activity in photosensitive participants with epilepsy. The AE profile of Staccato alprazolam was similar to what has been reported for alprazolam for other indications. The results support further development of Staccato alprazolam as a rescue medication for the acute treatment of seizures.
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