Development of a Multiprotein Classifier for the Detection of Early Stage Ovarian Cancer.
Kristin L M BoylanAshley PetersenTimothy K StarrXuan PuMelissa A GellerRobert C BastKaren H LuUgo CavallaroDenise C ConnollyKevin Meyer EliasDaniel W CramerTanja PejovicAmy P N SkubitzPublished in: Cancers (2022)
The inclusion of the proteins HE4, ITGAV, and SEZ6L improved the sensitivity and specificity of CA125 alone for the detection of early stages of ovarian cancer in serum samples. Furthermore, we identified several proteins that may be novel biomarkers of early stage ovarian cancer.