High uptake of 68Ga-PSMA and 18F-DCFPyL in the peritumoral area of rat gliomas due to activated astrocytes.

Dennis OliveiraCarina StegmayrAlexander HeinzelJohannes ErmertBernd NeumaierN Jon ShahFelix M MottaghyKarl-Josef LangenAntje Willuweit

Published in: EJNMMI research (2020)

High uptake of 68Ga-PSMA and 18F-DCFPyL in the peritumoral area of all glioma models is presumably caused by activated astrocytes. This may represent a limitation for the clinical application of PSMA ligands in gliomas.

Keyphrases

pet ct
high grade
positron emission tomography
oxidative stress
computed tomography