Circulating Histones and Severity of Illness in Children with Sepsis: A Prospective Observational Study.

Vishal SidanaJaved IsmailKarthi NallasamyPrateek BhatiaMuralidharan Jayashree

Published in: Indian journal of pediatrics (2022)

The present data provides early evidence that in children hospitalized with severe sepsis, histone H3 is not elevated as compared to healthy controls. H3 levels during initial days of sepsis requiring PICU admission were not different with regards to severity of illness, organ dysfunction, and clinical outcome. There was a trend towards elevated H3 in children with thrombocytopenia, which needs further evaluation.

Keyphrases

young adults
acute kidney injury
intensive care unit
septic shock
emergency department
machine learning
big data
deep learning
artificial intelligence