Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice.

Lin QiCheng WangLidong DengJia-Ji PanQian SuoShengju WuLin CaiXudong ShiJunfeng SunYongting WangYaohui TangWeibao QiuYongting Wang Jixian WangZhijun Zhang

Published in: Stroke and vascular neurology (2024)

Our results demonstrated that LIFUS promoted angiogenesis and synaptogenesis after focal cerebral ischaemia by upregulating HMGB1 and downregulating CAMK2N1 in a subcluster of astrocytes, suggesting that LIFUS activated specific astrocyte subcluster could be a key target for ischaemic brain therapy.

Keyphrases

cerebral ischemia
subarachnoid hemorrhage
atrial fibrillation
endothelial cells
white matter
high fat diet induced
resting state
vascular endothelial growth factor
brain injury
wound healing
metabolic syndrome
mesenchymal stem cells
insulin resistance
cell therapy