In vivo imaging of synaptic loss in Alzheimer's disease with [18F]UCB-H positron emission tomography.
Christine BastinMohamed Ali BahriFrançois MeyerMarine ManardEmma DelhayeAlain PlenevauxGuillaume BeckerAlain SeretChristine MellaFabrice GiacomelliChristian DegueldreEvelyne BalteauAndré LuxenEric SalmonPublished in: European journal of nuclear medicine and molecular imaging (2019)
The findings thus highlight predominant synaptic loss in the hippocampus, confirming previous autopsy-based studies and a recent PET study with an 11C-labelled SV2A radiotracer. [18F]UCB-H PET allows to image in vivo synaptic changes in Alzheimer's disease and to relate them to patients' cognitive impairment.
Keyphrases
- positron emission tomography
- computed tomography
- pet imaging
- cognitive impairment
- pet ct
- prefrontal cortex
- end stage renal disease
- cognitive decline
- newly diagnosed
- ejection fraction
- chronic kidney disease
- high resolution
- peritoneal dialysis
- prognostic factors
- machine learning
- patient reported outcomes
- blood brain barrier