Osteogenic Response of MC3T3-E1 and Raw264.7 in the 3D-Encapsulated Co-Culture Environment.

Jungju KimHao-Zhen LyuChisung JungKyung Mee LeeShi Huan HanJae Hyup LeeMisun Cha

Published in: Tissue engineering and regenerative medicine (2021)

In this study, the osteogenic response of 3D encapsulated pre-osteoblast MC3T3-E1 cells and mouse monocyte Raw264.7 cells was successfully demonstrated. Our 3D culture conditions will be able to provide a foundation for developing a high-throughput in vitro bone model to study the effects of various drugs and other agents on molecular pathways.

Keyphrases

induced apoptosis
high throughput
mesenchymal stem cells
bone marrow
dendritic cells
endoplasmic reticulum stress
oxidative stress
signaling pathway
drug induced