Optimizing treatment persistence in epilepsy: a comparative analysis of combined antiseizure medications with different mechanisms of action.
Chun-Wei ChangWei-En Johnny TsengWey-Ran LinPo-Chuan KoChun-Jing LiuSiew-Na LimPublished in: Therapeutic advances in neurological disorders (2023)
ASM combinations with different MoAs had superior efficacy and tolerability to ASM combinations with similar MoAs, particularly SC and M combinations. In our cohort, factors associated with treatment discontinuation included underlying malignancy, male sex, and renal disease. These findings may provide valuable insights into the use of ASM combinations if monotherapy cannot adequately control seizures.