Protective Role of the M-Sec-Tunneling Nanotube System in Podocytes.
Federica BaruttaShunsuke KimuraKoji HaseStefania BelliniBeatrice CorbettaAlessandro CorbelliFabio FiordalisoAntonella BarrecaMauro Giulio PapottiGian Marco GhiggeriGennaro SalvidioDario RoccatelloValentina AudritoSilvia DeaglioRoberto GambinoStefania BrunoGiovanni CamussiMiriam MartiniEmilio HirschMarilena DurazzoHiroshi OhnoGabriella GrudenPublished in: Journal of the American Society of Nephrology : JASN (2021)
These findings indicate that the M-Sec-TNT system plays an important protective role in the glomeruli by rescuing podocytes via mitochondrial horizontal transfer. M-Sec may represent a promising therapeutic target in FSGS, and evidence that podocytes can be rescued via TNT-mediated horizontal transfer may open new avenues of research.