DEP Domain-Containing Protein 1B (DEPDC1B) Promotes Migration and Invasion in Pancreatic Cancer Through the Rac1/PAK1-LIMK1-Cofilin1 Signaling Pathway.

Shan ZhangWeiwei ShiWei HuDing MaDongliang YanKuanyong YuGuang ZhangYin CaoJunhua WuChunping JiangZhongxia Wang

Published in: OncoTargets and therapy (2020)

DEPDC1B promoted cell migration and invasion by activating the Rac1/PAK1-LIMK1-cofilin1 signaling pathway, thus providing a potential therapeutic target against PC.

Keyphrases

signaling pathway
pi k akt
epithelial mesenchymal transition
induced apoptosis
single cell
cell migration
cell therapy
protein protein
oxidative stress
binding protein
cell proliferation
risk assessment
human health