A role for macrophages under cytokine control in mediating resistance to ADI-PEG20 (pegargiminase) in ASS1-deficient mesothelioma.

Melissa M PhillipsIuliia PavlykMichael AllenEssam GhazalyRosalind CuttsJosephine CarpentierJoe Scott BerryCallum NattressShenghui FengGunnel HalldenClaude ChelalaJohn BomalaskiJeremy SteeleMichael SheaffFrances BalkwillPeter W Szlosarek

Published in: Pharmacological reports : PR (2023)

Collectively, our data indicate that ADI-PEG20-inducible cytokines orchestrate argininosuccinate fuelling of ASS1-deficient mesothelioma by macrophages. This novel stromal-mediated resistance pathway may be leveraged to optimize arginine deprivation therapy for mesothelioma and related arginine-dependent cancers.

Keyphrases

nitric oxide
drug delivery
bone marrow
electronic health record
amino acid
big data
drug induced
childhood cancer