KDELR2 promotes breast cancer proliferation via HDAC3-mediated cell cycle progression.

Haoran WeiWenhao MaXiaofei LuHaiying LiuKashuai LinYinghui WangZijian YeLinchong SunZhitong HuangTingting PanZilong ZhouEric Y ChengHuafeng ZhangPing GaoXiuying Zhong

Published in: Cancer communications (London, England) (2021)

Our results uncovered a previously unappreciated function of KDELR2 in tumorigenesis, linking a critical Golgi-the endoplasmic reticulum traffic transport protein to HDAC-controlled cell cycle progression on the path of cancer development and thus revealing a potential therapeutical target for breast cancer.

Keyphrases

cell cycle
endoplasmic reticulum
cell proliferation
histone deacetylase
air pollution
signaling pathway
squamous cell
squamous cell carcinoma
amino acid
risk assessment
small molecule