CD30-targeted therapy induces apoptosis of inflammatory cytokine-stimulated synovial fibroblasts and ameliorates collagen antibody-induced arthritis in mice.
Minami MatsuhashiKeiichiro NishidaMisa SakamotoYuka GionAki YoshidaTakayuki KatsuyamaRyuichi NakaharaYoshihisa NasuYoshinori MatsumotoYasuharu SatoToshifumi OzakiPublished in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2022)
CD30 was expressed on immunocompetent cells in synovial tissue from RA patients and in cytokine-stimulated FLS in vitro. High dose BV (70 mg/kg) showed significant therapeutic effects in ameliorating inflammation and joint destruction in CAIA mice, but low dose BV (30 mg/kg) was insufficient.
Keyphrases
- high dose
- low dose
- rheumatoid arthritis
- end stage renal disease
- oxidative stress
- ejection fraction
- induced apoptosis
- lps induced
- lipopolysaccharide induced
- newly diagnosed
- high fat diet induced
- peritoneal dialysis
- prognostic factors
- high glucose
- type diabetes
- cell cycle arrest
- inflammatory response
- endothelial cells
- disease activity
- adipose tissue
- extracellular matrix
- ankylosing spondylitis
- patient reported
- pi k akt