Conditional knockout of AIM2 in microglia ameliorates synaptic plasticity and spatial memory deficits in a mouse model of Alzheimer's disease.

Lei YeMengsha HuRui MaoYi TanMin SunJunqiu JiaSiyi XuYi LiuXiao-Lei Zhu Yun Xu Feng Bai Shu Shu

Published in: CNS neuroscience & therapeutics (2023)

Our results demonstrated that microglial AIM2 plays a critical role in regulating synaptic plasticity and memory deficits associated with AD, providing a new direction for developing novel preventative and therapeutic interventions for this disease.

Keyphrases

mouse model
traumatic brain injury
inflammatory response
working memory
physical activity
cognitive decline
spinal cord injury