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Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia.

Jaime Sanz-CánovasAlmudena López-SampaloLidia Cobos-PalaciosMichele RicciHalbert Hernandez-NegrinJuan José Mancebo-SevillaElena Álvarez-RecioMaría Dolores López-CarmonaLuis Miguel Pérez-BelmonteRicardo Gómez-HuelgasMaria Rosa Bernal-López
Published in: International journal of environmental research and public health (2022)
The life expectancy of the population is increasing worldwide due to improvements in the prevention, diagnosis, and treatment of diseases. This favors a higher prevalence of type 2 diabetes mellitus (T2DM) in the elderly. Sarcopenia and frailty are also frequently present in aging. These three entities share common mechanisms such as insulin resistance, chronic inflammation, and mitochondrial dysfunction. The coexistence of these situations worsens the prognosis of elderly patients. In this paper, we review the main measures for the prevention and management of sarcopenia and/or frailty in elderly patients with T2DM.
Keyphrases
  • community dwelling
  • insulin resistance
  • oxidative stress
  • skeletal muscle
  • type diabetes
  • adipose tissue
  • glycemic control
  • metabolic syndrome
  • high fat diet
  • polycystic ovary syndrome