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Microbiota and B-1 B cell repertoire development in mice.

James Stewart NewRodney Glenn KingJeremy B FooteJohn F Kearney
Published in: Current opinion in immunology (2024)
Microbiota-derived antigens play a critical role in the development of both the mucosal and systemic B cell repertoires; however, how glycan epitopes promote B cell repertoire selection is only recently being understood. The production of glycan-derived antigens by individual microbes within a host can be dynamic and influenced by interactions within other members of microbial communities, the composition of diet, and host-derived contents, including those of the mucosal immune system. The size and complexity of the emerging neonatal B cell repertoire are paralleled by the acquisition of a diverse microbiota from maternal and environmental sources, which is now appreciated to exert long-lasting influences on the nascent B cell repertoire.
Keyphrases
  • high throughput sequencing
  • pregnant women
  • immune response
  • weight loss
  • body mass index
  • birth weight
  • insulin resistance
  • skeletal muscle
  • high fat diet induced