Conservative Management of Complicated Colonic Diverticulitis in Early and Late Elderly.
Gennaro PerroneGiuffrida MarioElena BonatiGabriele Luciano PetraccaAntonio TarasconiGian Luca BaiocchiFausto CatenaPublished in: Medicina (Kaunas, Lithuania) (2021)
Background and Objectives : The management of complicated diverticulitis in the elderly can be a challenge and initial non-operative treatment remains controversial. In this study, we investigate the effectiveness of conservative treatment in elderly people after the first episode of complicated diverticulitis. Materials and Methods : This retrospective single-centre study describes 71 cases of elderly patients with complicated acute colonic diverticulitis treated with conservative management at Parma University Hospital from 1 January 2012 to 31 December 2019. Diverticulitis severity was staged according to WSES CT driven classification for acute diverticulitis. Patients was divided into two groups: early (65-74 yo) and late elderly (>75 yo). Results : We enrolled 71 elderly patients conservatively treated for complicated acute colonic diverticulitis, 25 males and 46 females. The mean age was 74.78 ± 6.8 years (range 65-92). Localized abdominal pain and fever were the most common symptoms reported in 34 cases (47.88%). Average white cells count was 10.04 ± 5.05 × 109/L in the early elderly group and 11.24 ± 7.89 in the late elderly group. CRP was elevated in 29 (78.3%) cases in early elderly and in 23 late elderly patients (67.6%). A CT scan of the abdomen was performed in every case (100%). Almost all patients were treated with bowel rest and antibiotics (95.7%). Average length of stay was 7.74 ± 7.1 days (range 1-48). Thirty-day hospital readmission and mortality were not reported. Average follow-up was 52.32 ± 31.8 months. During follow-up, home therapy was prescribed in 48 cases (67.6%). New episodes of acute diverticulitis were reported in 20 patients (28.1%), elevated WBC and chronic NSAID therapy were related to a higher risk of recurrence in early elderly patients ( p < 0.05). Stage IIb-III with elevated WBC during first episode, had a higher recurrence rate compared to the other CT-stage ( p = 0.006). Conclusions : The management of ACD in the elderly can be a challenge. Conservative treatment is safe and effective in older patients, avoiding unnecessary surgery that can lead to unexpected complications due to co-morbidities.
Keyphrases
- middle aged
- end stage renal disease
- newly diagnosed
- liver failure
- community dwelling
- ejection fraction
- chronic kidney disease
- computed tomography
- prognostic factors
- healthcare
- peritoneal dialysis
- drug induced
- emergency department
- induced apoptosis
- systematic review
- signaling pathway
- cardiovascular disease
- bone marrow
- patient reported outcomes
- depressive symptoms
- cell death
- oxidative stress
- physical activity
- magnetic resonance imaging
- deep learning
- atrial fibrillation
- positron emission tomography
- extracorporeal membrane oxygenation
- acute respiratory distress syndrome
- patient reported
- dual energy
- acute coronary syndrome
- free survival
- electronic health record
- mechanical ventilation