Hydrogels Based on Imino-Chitosan Amphiphiles as a Matrix for Drug Delivery Systems.
Daniela AilincaiWilliam PorzioLuminita MarinPublished in: Polymers (2020)
This paper reports new formulations based on chitosan, citral, and diclofenac sodium salt (DCF). The central idea was to encapsulate an anionic drug into a polycationic hydrogel matrix in order to increase the intermolecular forces between them and thus to ensure slower drug release, while citral was used as a penetration enhancer to assure efficient delivery of the drug. Hydrogels without drug were also synthesized and used as a reference. The structure, morphology, and supramolecular architecture of the drug delivery systems were evaluated by FTIR spectroscopy, scanning electron microscopy, polarized optical microscopy, and wide-angle X-ray diffraction. The drug release kinetics was monitored in vitro by UV-VIS spectroscopy, in physiological conditions, while the enzymatic and hydrolytic degradability of the hydrogels were evaluated in the presence of lysozyme and phosphate buffer saline (PBS), at 37 °C. All of the data revealed that the anionic DCF was strongly anchored into the polycationic matrix and the drug was slowly released over 7 days. Moreover, the release rate can be controlled by simple variation of the molar ratio between the polycationic chitosan and lipophilic citral.
Keyphrases
- drug release
- drug delivery
- high resolution
- electron microscopy
- hyaluronic acid
- wound healing
- single molecule
- adverse drug
- drug induced
- mass spectrometry
- hydrogen peroxide
- high speed
- optical coherence tomography
- emergency department
- computed tomography
- extracellular matrix
- machine learning
- tissue engineering
- single cell
- label free