Synthesis, spectroscopic characterization, and antibacterial activity of chalcone (2E)-1-(3'-aminophenyl)-3-(4-dimethylaminophenyl)-prop-2-en-1-one against multiresistant Staphylococcus aureus carrier of efflux pump mechanisms and β-lactamase.
Larissa da SilvaIsydório Alves DonatoSuieny Rodrigues BezerraHélcio Silva Dos SantosPaulo Nogueira BandeiraMaria Thalia Ramos do NascimentoJesyka Macêdo GuedesPriscila Ramos FreitasAna Carolina Justino de AraújoThiago Sampaio de FreitasHenrique Doouglas Melo CoutinhoYedda Maria Lobo Soares de MatosLígia Cláudia Castro de OliveiraFrancisco Assis Bezerra da CunhaPublished in: Fundamental & clinical pharmacology (2023)
We conclude that the chalcone synthesized in this study is a promising substance to combat bacterial resistance, possibly acting in the inhibition of the QacC efflux pump present in S. aureus strain K4100, as evidenced by the reduction in the MIC of ethidium bromide.