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Updated Overall Survival and PD-L1 Subgroup Analysis of Patients With Extensive-Stage Small-Cell Lung Cancer Treated With Atezolizumab, Carboplatin, and Etoposide (IMpower133).

Stephen V LiuMartin ReckAaron S MansfieldTony MokArnaud ScherpereelNiels ReinmuthMarina Chiara GarassinoJavier De Castro CarpeñoRaffaele CalifanoMakoto NishioFrancisco OrlandiJorge Alatorre-AlexanderTiciana A LealYing ChengJong-Seok LeeSivuonthanh LamMark McClelandYu DengSee PhanLeora Horn
Published in: Journal of clinical oncology : official journal of the American Society of Clinical Oncology (2021)
Adding atezolizumab to CP/ET as 1L treatment for ES-SCLC continued to demonstrate improved OS and a tolerable safety profile at the updated analysis, confirming the regimen as a new standard of care. Exploratory analyses demonstrated treatment benefit independent of biomarker status.
Keyphrases
  • small cell lung cancer
  • healthcare
  • palliative care
  • clinical trial
  • radiation therapy
  • combination therapy
  • squamous cell carcinoma
  • quality improvement
  • brain metastases