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Serologic biomarkers in Candida and Aspergillus infections of the central nervous system: A comparison of galactomannan, mannan and β-1,3-D-gucan testing from serum and cerebrospinal fluid.

Johannes ForsterMartin HoeniglSebastian SuerbaumJohannes WagenerKarl Dichtl
Published in: Mycoses (2022)
Sensitivity for diagnosing CNS aspergillosis and CNS candidiasis from serum is mediocre for all serological biomarkers. GM testing in CSF proved excellent performance. With a sensitivity of 100% but a specificity of only 70%, CSF BDG might be most useful when used in patients with a high pre-test probability.
Keyphrases
  • cerebrospinal fluid
  • candida albicans
  • blood brain barrier
  • biofilm formation
  • cystic fibrosis
  • pseudomonas aeruginosa
  • coronavirus disease
  • structural basis