Effect of a Single Apolipoprotein L1 Gene Nephropathy Variant on the Risk of Advanced Lupus Nephritis in Brazilians.

Gisele VajgelSuelen Cristina LimaDiego Jeronimo S SantanaCamila B L OliveiraDenise Maria N CostaPamela J HicksMaria Alina G M CavalcanteCarl D LangefeldLucila Maria ValenteSergio CrovellaGianna Mastroianni KirsztajnBarry I FreedmanPaula Sandrin-Garcia

Published in: The Journal of rheumatology (2019)

Although initial kidney lesions and treatment responses were similar, a single APOL1 RRA in nonwhite Brazilians with LN was associated with increased risk of advanced CKD and possibly more tubulointerstitial damage.

Keyphrases

chronic kidney disease
oxidative stress
genome wide
gene expression
dna methylation
combination therapy
diabetic nephropathy